Direct N–O bond formation via oxidation of amines with benzoyl peroxide
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چکیده
منابع مشابه
Direct electrochemical imidation of aliphatic amines via anodic oxidation.
Direct electrochemical synthesis of sulfonyl amidines from aliphatic amines and sulfonyl azides was realized with good to excellent yields. Traditional tertiary amine substrates were broadened to secondary and primary amines. The reaction intermediates were observed and a reaction mechanism was proposed and discussed.
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The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.
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A simple, sensitive, spectrophotometric method in UV region has been developed for the simultaneous estimation of benzoyl peroxide and tretinoin in bulk and semi solid dosage form (cream). Standard solution of benzoyl peroxide shows maximum absorbance at 234.8 nm and tretinoin shows maximum absorbance at 348.6 nm. Beer’s Lamberts law is obeyed in concentration range 1-9 μg/ml for tretinoin with...
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Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding alpha-aminonitriles, which are highly useful intermediates for organic synthesis. The reaction is the first demonstration of direct sp(3) C-H bond activation alpha to nitrogen followed by carbon-carbon bond formation under aerobic oxidation c...
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Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2019
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c8sc04996c